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  Drosophila MCRS2 Associates with RNA Polymerase II Complexes To Regulate Transcription

Andersen, D. S., Raja, S. J., Colombani, J., Shaw, R. L., Langton, P. F., Akhtar, A., et al. (2010). Drosophila MCRS2 Associates with RNA Polymerase II Complexes To Regulate Transcription. Molecular and Cellular Biology (Washington, DC), 30, 4744-4755. doi:10.1128/MCB.01586-09.

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 Creators:
Andersen, Ditte Skovaa1, Author
Raja, Sunil Jayaramaiah2, Author              
Colombani, Julien1, Author
Shaw, Rachael Louise1, Author
Langton, Paul Francis1, Author
Akhtar, Asifa3, Author              
Tapon, Nicolas1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243644              
3Department of Chromatin Regulation, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243643              

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 Abstract: Drosophila MCRS2 (dMCRS2; MCRS2/MSP58 and its splice variant MCRS1/p78 in humans) belongs to a family of forkhead-associated (FHA) domain proteins. Whereas, human MCRS2 proteins have been associated with a variety of cellular processes, including RNA polymerase I transcription and cell cycle progression, dMCRS2 has been largely uncharacterized. Recent data show that MCRS2 is purified as part of a complex containing the histone acetyltransferase MOF (males absent on first) in both humans and flies. MOF mediates H4K16 acetylation and regulates the expression of a large number of genes, suggesting that MCRS2 could also have a function in transcription regulation. Here, we show that dMCRS2 copurifies with RNA polymerase II (RNAP II) complexes and localizes to the 5' ends of genes. Moreover, dMCRS2 is required for optimal recruitment of RNAP II to the promoter regions of cyclin genes. In agreement with this, dMCRS2 is required for normal levels of cyclin gene expression. We propose a model whereby dMCRS2 promotes gene transcription by facilitating the recruitment of RNAP II preinitiation complexes (PICs) to the promoter regions of target genes.

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Language(s): eng - English
 Dates: 2010-10
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1128/MCB.01586-09
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Title: Molecular and Cellular Biology (Washington, DC)
  Other : Mol Cell Biol
Source Genre: Journal
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Publ. Info: American Society for Microbiology (ASM)
Pages: - Volume / Issue: 30 Sequence Number: - Start / End Page: 4744 - 4755 Identifier: ISSN: 0270-7306
CoNE: https://pure.mpg.de/cone/journals/resource/954925502188