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  Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex

Liefke, R., Oswald, F., Alvarado, C., Ferres-Marco, D., Mittler, G., Rodriguez, P., et al. (2010). Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex. Genes & Development, 24, 590-601.

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 Creators:
Liefke, Robert1, Author           
Oswald, Franz, Author
Alvarado, Cristobal, Author
Ferres-Marco, Dolores, Author
Mittler, Gerhard1, Author           
Rodriguez, Patrick1, Author           
Dominguez, Maria, Author
Borggrefe, Tilman1, Author           
Affiliations:
1Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

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Free keywords: Histone demethylase; RBP-J; Notch target gene repression; T cells; Drosophila; tumorigenesis
 Abstract: Timely acquisition of cell fates and the elaborate control of growth in numerous organs depend on Notch signaling. Upon ligand binding, the core transcription factor RBP-J activates transcription of Notch target genes. In the absence of signaling, RBP-J switches off target gene expression, assuring the tight spatiotemporal control of the response by a mechanism incompletely understood. Here we show that the histone demethylase KDM5A is an integral, conserved component of Notch/RBP-J gene silencing. Methylation of histone H3 Lys 4 is dynamically erased and re-established at RBP-J sites upon inhibition and reactivation of Notch signaling. KDM5A interacts physically with RBP-J; this interaction is conserved in Drosophila and is crucial for Notch-induced growth and tumorigenesis responses.

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Language(s): eng - English
 Dates: 2010
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 529882
 Degree: -

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Title: Genes & Development
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 24 Sequence Number: - Start / End Page: 590 - 601 Identifier: -