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  Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism

Messerschmidt, D. M., & Kemler, R. (2010). Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism. Developmental Biology, 344, 129-137.

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資料種別: 学術論文

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 作成者:
Messerschmidt, Daniel M., 著者
Kemler, Rolf1, 著者           
所属:
1Emeritus Group: Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243656              

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キーワード: Nanog; Epiblast; Primitive endoderm; Trophectoderm; Blastocyst
 要旨: Early lineage segregation in mouse development results in two, either CDX2- or OCT4/NANOG-positive, cell populations. CDX2-positive cells form the trophectoderm (TE), OCT4/NANOG-positive cells the inner cell mass (ICM). In a second lineage decision ICM cells segregate into Epiblast (EPI) and primitive endoderm (PE). EPI and PE formation depend on the activity of the transcription factors Nanog and Gata4/6. A role for Nanog, a crucial pluripotency factor, in preventing PE differentiation has been proposed, as outgrowths of mutant ICMs result in PE, but not EPI derivatives. We established Nanog-mutant mouse lines and analyzed EPI and PE formation in vivo. Surprisingly, Gata4 expression in mutant ICM cells is absent or strongly decreased, thus loss of Nanog does not result in precocious endoderm differentiation. However, Nanog-deficient embryos retain the capacity to form PE in chimeric embryos and, in contrast to recent reports, in blastocyst outgrowths. Based on our findings we propose a non-cell autonomous requirement of Nanog for proper PE formation in addition to its essential role in EPI determination.

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言語: eng - English
 日付: 2010
 出版の状態: 出版
 ページ: -
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 目次: -
 査読: 査読あり
 識別子(DOI, ISBNなど): eDoc: 529910
 学位: -

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出版物 1

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出版物名: Developmental Biology
  出版物の別名 : Dev. Biol.
種別: 学術雑誌
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出版社, 出版地: -
ページ: - 巻号: 344 通巻号: - 開始・終了ページ: 129 - 137 識別子(ISBN, ISSN, DOIなど): -