English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Role of PI3K in the generation and survival of B cells

Werner, M., Hobeika, E., & Hassan, J. (2010). Role of PI3K in the generation and survival of B cells. Immunological Reviews, 237, 55-71.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Werner, Markus1, Author           
Hobeika, Elias1, Author           
Hassan, Jumaa2, Author
Affiliations:
1Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243645              
2Max Planck Society, ou_persistent13              

Content

show
hide
Free keywords: B cells; PI3K; survival; basal BCR signal
 Abstract: Engagement of the B-cell antigen receptor (BCR) or its precursor, the pre-BCR, induces a cascade of biochemical reactions that regulate the differentiation, selection, survival, and activation of B cells. This cascade is initiated by receptor-associated tyrosine kinases that activate multiple downstream signaling pathways. Since it is required for metabolism, cell growth, development, and survival, the activation of phosphoinositide 3-kinase (PI3K)-dependent pathways represents a crucial event of BCR/pre-BCR signaling. The phosphorylated substrates of the PI3K promote specific recruitment of selected signaling proteins to the plasma membrane, where important signaling complexes are formed to mediate the above-mentioned biological processes. Here, we review the principles of PI3K signaling and highlight the role of an important PI3K-driven module in VDJ recombination of immunoglobulin (Ig) genes during early B-cell development as compared with class switch recombination of Ig genes in mature B cells after activation by specific antigens. Furthermore, we discuss the role of PI3K in the survival of mature B cells, which is strictly dependent on BCR expression and basal BCR signaling.

Details

show
hide
Language(s): eng - English
 Dates: 2010
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 541481
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Immunological Reviews
  Alternative Title : Immunol. Rev.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 237 Sequence Number: - Start / End Page: 55 - 71 Identifier: -