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  Evolution of Genetic Networks Underlying the Emergence of Thymopoiesis in Vertebrates

Bajoghli, B., Aghaallaei, N., Hess, I., Rode, I., Netuschil, N., Tay, B.-H., et al. (2009). Evolution of Genetic Networks Underlying the Emergence of Thymopoiesis in Vertebrates. Cell, 138, 186-197. doi:10.1016/j.cell.2009.04.017.

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Bajoghli, Baubak1, Author              
Aghaallaei, Narges1, Author              
Hess, Isabell1, Author              
Rode, Immanuel1, Author              
Netuschil, Nikolai1, Author              
Tay, Boon-Hui2, Author
Venkatesh, Byrappa2, Author
Yu, Jr-Kai2, Author
Kaltenbach, Stacy L.2, Author
Holland, Nicholas D.2, Author
Diekhoff, Dagmar1, Author              
Happe, Christiane1, Author              
Schorpp, Michael1, Author              
Boehm, Thomas1, Author              
Affiliations:
1Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              
2External Organizations, ou_persistent22              

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 Abstract: About 500 million years ago, a new type of adaptive immune defense emerged in basal jawed vertebrates, accompanied by morphological innovations, including the thymus. Did these evolutionary novelties arise de novo or from elaboration of ancient genetic networks? We reconstructed the genetic changes underlying thymopoiesis by comparative genome and expression analyses in chordates and basal vertebrates. The derived models of genetic networks were experimentally verified in bony fishes. Ancestral networks defining circumscribed regions of the pharyngeal epithelium of jawless vertebrates expanded in cartilaginous fishes to incorporate novel genes, notably those encoding chemokines. Correspondingly, novel networks evolved in lymphocytes of jawed vertebrates to control the expression of additional chemokine receptors. These complementary changes enabled unprecedented Delta/Notch signaling between pharyngeal epithelium and lymphoid cells that was exploited for specification to the T cell lineage. Our results provide a framework elucidating the evolution of key features of the adaptive immune system in jawed vertebrates.

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Language(s): eng - English
 Dates: 2009-07-10
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.cell.2009.04.017
 Degree: -

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Title: Cell
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 138 Sequence Number: - Start / End Page: 186 - 197 Identifier: ISSN: 0092-8674
CoNE: https://pure.mpg.de/cone/journals/resource/954925463183