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  H3K64 trimethylation marks heterochromatin and is dynamically remodeled during developmental reprogramming

Daujat, S., Weiss, T., Mohn, F., Lange, U. C., Ziegler-Birling, C., Zeissler, U., et al. (2009). H3K64 trimethylation marks heterochromatin and is dynamically remodeled during developmental reprogramming. Nature Structural & Molecular Biology, 16, 777-781.

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 Creators:
Daujat, Sylvain1, Author              
Weiss, Thomas1, Author              
Mohn, Fabio, Author
Lange, Ulrike C.1, Author              
Ziegler-Birling, Céline, Author
Zeissler, Ulrike1, Author              
Lappe, Michael, Author
Schübeler, Dirk, Author
Torres-Padilla, Maria-Elena, Author
Schneider, Robert1, Author              
Affiliations:
1Spemann Laboratory, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243655              

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 Abstract: Histone modifications are central to the regulation of all DNA-dependent processes. Lys64 of histone H3 (H3K64) lies within the globular domain at a structurally important position. We identify trimethylation of H3K64 (H3K64me3) as a modification that is enriched at pericentric heterochromatin and associated with repeat sequences and transcriptionally inactive genomic regions. We show that this new mark is dynamic during the two main epigenetic reprogramming events in mammals. In primordial germ cells, H3K64me3 is present at the time of specification, but it disappears transiently during reprogramming. In early mouse embryos, it is inherited exclusively maternally; subsequently, the modification is rapidly removed, suggesting an important role for H3K64me3 turnover in development. Taken together, our findings establish H3K64me3 as a previously uncharacterized histone modification that is preferentially localized to repressive chromatin. We hypothesize that H3K64me3 helps to 'secure' nucleosomes, and perhaps the surrounding chromatin, in an appropriately repressed state during development.

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Language(s): eng - English
 Dates: 2009
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: eDoc: 447206
 Degree: -

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Title: Nature Structural & Molecular Biology
  Alternative Title : Nat. Struct. Mol. Biol.
Source Genre: Journal
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Pages: - Volume / Issue: 16 Sequence Number: - Start / End Page: 777 - 781 Identifier: -