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  Models of Antigen Receptor Activation in the Design of Vaccines

Molnár, E., Dopfer, E.-P., Deswal, S., & Schamel, W. W. A. (2009). Models of Antigen Receptor Activation in the Design of Vaccines. Current Pharmaceutical Design, 15, 3237-3248.

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Molnár, Esther1, Autor           
Dopfer, Elaine-Pashupati1, Autor           
Deswal, Sumit1, Autor           
Schamel, Wolfgang W. A.1, Autor           
Affiliations:
1Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243645              

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Schlagwörter: Vaccine, T cell, B cell, clustering, immune response, tumor, autoimmunity
 Zusammenfassung: Vaccination techniques have developed rapidly over the last several decades from the immunization with live attenuated pathogens to the use of peptide and DNA subunit vaccines, from the use of classical adjuvants to cell-directed delivery. Vaccination techniques are also under investigation for the treatment of tumors and autoimmune diseases. However, profound knowledge of activation mechanisms of the immune cells on a molecular level is prerequisite for a better understanding of the immune response, and for the development of effective immunomodulatory tools. In this review we discuss the models of BCR and TCR activation, and using the example of some vacciantion technologies, we show, how the understanding of these models could help in the design of a new generation of vaccines.

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Sprache(n): eng - English
 Datum: 2009
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 463814
 Art des Abschluß: -

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Titel: Current Pharmaceutical Design
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 15 Artikelnummer: - Start- / Endseite: 3237 - 3248 Identifikator: -