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  Neural progenitors of the Postnatal and Adult Mouse Forebrain Retain the Ability to Self-Replicate, Form Neurospheres, and Undergo Multipotent Differentiation In Vivo

Neumeister, B., Grabosch, A., Basak, O., Kemler, R., & Taylor, V. (2009). Neural progenitors of the Postnatal and Adult Mouse Forebrain Retain the Ability to Self-Replicate, Form Neurospheres, and Undergo Multipotent Differentiation In Vivo. Stem Cells, 27, 714-723.

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資料種別: 学術論文

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 作成者:
Neumeister, Bettina1, 著者           
Grabosch, Antje2, 著者           
Basak, Onur2, 著者           
Kemler, Rolf1, 著者           
Taylor, Verdon1, 著者           
所属:
1Emeritus Group: Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243656              
2Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243651              

内容説明

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キーワード: Neural stem cells, Neurogenesis, Subventricular zone, Transplantation
 要旨: Somatic stem cells are reservoirs to replace lost cells or damaged tissue. Cells with neural stem cell (NSC) characteristics can be isolated from the postnatal mammalian brain into adulthood and expanded as neurospheres. We addressed the ability of these in vitro expanded putative NSCs to retain progenitor characteristics in vivo, in analogy to hematopoietic stem cells. When transplanted in utero, both postnatal and adult neural progenitors colonize host brains and contribute neurons and glia. In stark contrast to what has been reported when transplanted in postnatal hosts, epidermal growth factor-expanded cells also remain self-replicating and multipotent in vivo over many months and can be serially transplanted into multiple hosts. Surprisingly, embryonically transplanted NSCs remain in the neurogenic regions in adult hosts, where they express progenitor cell markers and continue to proliferate even after 6 months without tumor formation. These data indicate that spherogenic cells of the postnatal and adult mammalian brain retain their potential in vitro and in vivo throughout the life of the organism and beyond transplantation, which has important implications for cell replacement strategies.

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言語: eng - English
 日付: 2009
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子(DOI, ISBNなど): eDoc: 463932
 学位: -

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出版物 1

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出版物名: Stem Cells
種別: 学術雑誌
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出版社, 出版地: -
ページ: - 巻号: 27 通巻号: - 開始・終了ページ: 714 - 723 識別子(ISBN, ISSN, DOIなど): -