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  Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh

Favaro, R., Valotta, M., Ferri, A. L., Latorre, E., Mariani, J., Giachino, C., Lancini, C., Tosetti, V., Ottolenghi, S., Taylor, V., & Nicolis, S. K. (2009). Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. Nature Neuroscience, 12, 1248-1256.

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資料種別: 学術論文

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 作成者:
Favaro, Rebecca, 著者
Valotta, Manella, 著者
Ferri, Anna L.M., 著者
Latorre, Elisa, 著者
Mariani, Jessica, 著者
Giachino, Claudio1, 著者           
Lancini, Cesare, 著者
Tosetti, Valentina, 著者
Ottolenghi, Sergio, 著者
Taylor, Verdon2, 著者           
Nicolis, Silvia K., 著者
所属:
1Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243651              
2Emeritus Group: Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243656              

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 要旨: Neural stem cells (NSCs) are controlled by diffusible factors. The transcription factor Sox2 is expressed by NSCs and Sox2 mutations in humans cause defects in the brain and, in particular, in the hippocampus. We deleted Sox2 in the mouse embryonic brain. At birth, the mice showed minor brain defects; shortly afterwards, however, NSCs and neurogenesis were completely lost in the hippocampus, leading to dentate gyrus hypoplasia. Deletion of Sox2 in adult mice also caused hippocampal neurogenesis loss. The hippocampal developmental defect resembles that caused by late sonic hedgehog (Shh) loss. In mutant mice, Shh and Wnt3a were absent from the hippocampal primordium. A SHH pharmacological agonist partially rescued the hippocampal defect. Chromatin immunoprecipitation identified Shh as a Sox2 target. Sox2-deleted NSCs did not express Shh in vitro and were rapidly lost. Their replication was partially rescued by the addition of SHH and was almost fully rescued by conditioned medium from normal cells. Thus, NSCs control their status, at least partly, through Sox2-dependent autocrine mechanisms.

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言語: eng - English
 日付: 2009
 出版の状態: 出版
 ページ: -
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 査読: 査読あり
 識別子(DOI, ISBNなど): eDoc: 474945
 学位: -

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出版物 1

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出版物名: Nature Neuroscience
種別: 学術雑誌
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ページ: - 巻号: 12 通巻号: - 開始・終了ページ: 1248 - 1256 識別子(ISBN, ISSN, DOIなど): -