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  Resolution of Sister Centromeres Requires RanBP2-Mediated SUMOylation of Topoisomerase IIα

Dawlaty, M. M., Malureanu, L., Jeganathan, K. B., Kao, E., Sustmann, C., Tahk, S., et al. (2008). Resolution of Sister Centromeres Requires RanBP2-Mediated SUMOylation of Topoisomerase IIα. Cell, 133, 103-115.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-9005-E Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-9006-C
Genre: Zeitschriftenartikel

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 Urheber:
Dawlaty, Meelad M., Autor
Malureanu, Liviu, Autor
Jeganathan, Karthik B., Autor
Kao, Esther, Autor
Sustmann, Claudio1, Autor           
Tahk, Samuel, Autor
Shuai, K., Autor
Grosschedl, Rudolf1, Autor           
van Deursen, Jan M., Autor
Affiliations:
1Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

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 Zusammenfassung: RanBP2 is a nucleoporin with SUMO E3 ligase activity that functions in both nucleocytoplasmic transport and mitosis. However, the biological relevance of RanBP2 and the in vivo targets of its E3 ligase activity are unknown. Here we show that animals with low amounts of RanBP2 develop severe aneuploidy in the absence of overt transport defects. The main chromosome segregation defect in cells from these mice is anaphase-bridge formation. Topoisomerase IIα (Topo IIα), which decatenates sister centromeres prior to anaphase onset to prevent bridges, fails to accumulate at inner centromeres when RanBP2 levels are low. We find that RanBP2 sumoylates Topo IIα in mitosis and that this modification is required for its proper localization to inner centromeres. Furthermore, mice with low amounts of RanBP2 are highly sensitive to tumor formation. Together, these data identify RanBP2 as a chromosomal instability gene that regulates Topo IIα by sumoylation and suppresses tumorigenesis.

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Sprache(n): eng - English
 Datum: 2008-04-04
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 400317
 Art des Abschluß: -

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Titel: Cell
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 133 Artikelnummer: - Start- / Endseite: 103 - 115 Identifikator: -