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  Rotation and Asymmetric Development of the Zebrafish Heart Requires Directed Migration of Cardiac Progenitor Cells

Smith, K. A., Chocron, S., von der Hardt, S., de Pater, E., Soufan, A., Bussmann, J., et al. (2008). Rotation and Asymmetric Development of the Zebrafish Heart Requires Directed Migration of Cardiac Progenitor Cells. Developmental Cell, 14, 287-297.

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Smith, Kelly A., Autor
Chocron, Sonja, Autor
von der Hardt, Sophia1, Autor           
de Pater, Emma, Autor
Soufan, Alexander, Autor
Bussmann, Jeroen, Autor
Schulte-Merker, Stefan, Autor
Hammerschmidt, Matthias1, Autor           
Bakkers, Jeroen1, Autor           
Affiliations:
1Georges Köhler Laboratory, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243653              

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 Zusammenfassung: We have used high-resolution 4D imaging of cardiac progenitor cells (CPCs) in zebrafish to investigate the earliest left-right asymmetric movements during cardiac morphogenesis. Differential migratory behavior within the heart field was observed, resulting in a rotation of the heart tube. The leftward displacement and rotation of the tube requires hyaluronan synthase 2 expression within the CPCs. Furthermore, by reducing or ectopically activating BMP signaling or by implantation of BMP beads we could demonstrate that BMP signaling, which is asymmetrically activated in the lateral plate mesoderm and regulated by early left-right signals, is required to direct CPC migration and cardiac rotation. Together, these results support a model in which CPCs migrate toward a BMP source during development of the linear heart tube, providing a mechanism by which the left-right axis drives asymmetric development of the vertebrate heart.

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Sprache(n): eng - English
 Datum: 2008-02
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 402293
 Art des Abschluß: -

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Titel: Developmental Cell
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 14 Artikelnummer: - Start- / Endseite: 287 - 297 Identifikator: -