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  Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: Benefits and hazards of LPS hypersensitivity

Freudenberg, M. A., Tchaptchet, S., Keck, S., Fejer, G., Huber, M., Schütze, N., et al. (2008). Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: Benefits and hazards of LPS hypersensitivity. Immunobiology, 213, 193-203.

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 Creators:
Freudenberg, Marina A.1, Author           
Tchaptchet, Sandrine1, Author           
Keck, Simone2, Author           
Fejer, György1, Author           
Huber, Michael3, Author           
Schütze, Nicole, Author
Beutler, Bruce, Author
Galanos, Chris2, Author           
Affiliations:
1Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              
2Emeritus Group: Cellular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243649              
3Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243645              

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Free keywords: Bacterial infections; Interferons; Lipopolysaccharide; LPS hypersensitivity; TLR; TLR ligands; Viral infections
 Abstract: In this review, we summarize our investigations concerning the differential importance of CD14 and LBP in toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2)-mediated signaling by smooth and rough-form lipopolysaccharide (LPS) chemotypes and include the results obtained in studies with murine and human TLR4-transgenic mice. Furthermore, we present more recent data on the mechanisms involved in the induction of LPS hypersensitivity by bacterial and viral infections and on the reactivity of the hypersensitive host to non-LPS microbial ligands and endogenous mediators. Finally, the effects of pre-existing hypersensitivity on the course and outcome of a super-infection with Salmonella typhimurium or Listeria monocytogenes are summarized.

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Language(s): eng - English
 Dates: 2008
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 400578
 Degree: -

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Title: Immunobiology
Source Genre: Journal
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Pages: - Volume / Issue: 213 Sequence Number: - Start / End Page: 193 - 203 Identifier: -