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  Clustering Models

Schamel, W. W. A., & Reth, M. (2008). Clustering Models. Advances in Experimental Medicine and Biology, 640, 64-73.

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 Creators:
Schamel, Wolfgang W. A.1, Author              
Reth, Michael1, Author              
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1Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243645              

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 Abstract: Ligand binding to the multichain immune recognition receptors (MIRRs) leads to receptor triggering and subsequent lymphocyte activation. MIRR signal transduction pathways have been extensively studied, but it is still not clear how binding of the ligand to the receptor is initially communicated across the plasma membrane to the cells interior. Models proposed for MIRR triggering can be grouped into three categories. Firstly, ligand binding invokes receptor clustering, resulting in the approximation of kinases to the MIRR and receptor phosphorylation. Secondly, ligand binding induces a conformational change of the receptor. Thirdly, upon ligand-binding, receptors and kinases are segregated from phosphatases, leading to a net phosphorylation of the receptor. In this review, we focus on the homoclustering induced by multivalent ligands, the heteroclustering induced by simultaneous binding of the ligand to the MIRR and a coreceptor and the pseudodimer model.

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Language(s): eng - English
 Dates: 2008
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 402245
 Degree: -

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Title: Advances in Experimental Medicine and Biology
Source Genre: Journal
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Pages: - Volume / Issue: 640 Sequence Number: - Start / End Page: 64 - 73 Identifier: -