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  Normal Germ Line Establishment in Mice Carrying a Deletion of the Ifitm/Fragilis Gene Family Cluster

Lange, U. C., Adams, D. J., Caroline, L., Barton, S., Schneider, R., Bradley, A., et al. (2008). Normal Germ Line Establishment in Mice Carrying a Deletion of the Ifitm/Fragilis Gene Family Cluster. Molecular and Cellular Biology, 28, 4688-4696.

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 Creators:
Lange, Ulrike C.1, Author           
Adams, David J., Author
Caroline, Lee, Author
Barton, Sheila, Author
Schneider, Robert1, Author           
Bradley, Allan, Author
Surani, M. Azim, Author
Affiliations:
1Spemann Laboratory, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243655              

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 Abstract: The family of interferon-inducible transmembrane proteins (Ifitm) consists of five highly sequence-related cell surface proteins, which are implicated in diverse cellular processes. Ifitm genes are conserved, widely expressed, and characteristically found in genomic clusters, such as the 67-kb Ifitm family locus on mouse chromosome 7. Recently, Ifitm1 and Ifitm3 have been suggested to mediate migration of early primordial germ cells (PGCs), a process that is little understood. To investigate Ifitm function during germ cell development, we used targeted chromosome engineering to generate mutants which either lack the entire Ifitm locus or carry a disrupted Ifitm3 gene only. Here we show that the mutations have no detectable effects on development of the germ line or on the generation of live young. Hence, contrary to previous reports, Ifitm genes are not essential for PGC migration. The Ifitm family is a striking example of a conserved gene cluster which appears to be functionally redundant during development.

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Language(s): eng - English
 Dates: 2008
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: eDoc: 402616
 Degree: -

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Title: Molecular and Cellular Biology
  Alternative Title : Mol. Cell. Biol.
Source Genre: Journal
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Pages: - Volume / Issue: 28 Sequence Number: - Start / End Page: 4688 - 4696 Identifier: -