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  RNA-Binding Protein Dnd1 Inhibits MicroRNA Access to Target mRNA

Kedde, M., Strasser, M. J., Boldajipour, B., Oude Vrielink, J. A. F., Slanchev, K., le Sage, C., et al. (2007). RNA-Binding Protein Dnd1 Inhibits MicroRNA Access to Target mRNA. Cell, 131, 1273-1286.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-916E-9 Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-916F-7
Genre: Zeitschriftenartikel

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 Urheber:
Kedde, Martijn, Autor
Strasser, Markus J., Autor
Boldajipour, Bijan, Autor
Oude Vrielink, Joachim A. F., Autor
Slanchev, Krasimir1, Autor           
le Sage, Carlos, Autor
Nagel, Remco, Autor
Voorhoeve, P. Mathijs, Autor
van Duijse, Josyanne, Autor
Orom, Ulf Andersson, Autor
Lund, Anders H., Autor
Perrakis, Anastassis, Autor
Raz, Erez, Autor
Agami, Reuven, Autor
Affiliations:
1Georges Köhler Laboratory, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243653              

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Schlagwörter: -
 Zusammenfassung: MicroRNAs (miRNAs) are inhibitors of gene expression capable of controlling processes in normal development and cancer. In mammals, miRNAs use a seed sequence of 6-8 nucleotides (nt) to associate with 3' untranslated regions (3'UTRs) of mRNAs and inhibit their expression. Intriguingly, occasionally not only the miRNA-targeting site but also sequences in its vicinity are highly conserved throughout evolution. We therefore hypothesized that conserved regions in mRNAs may serve as docking platforms for modulators of miRNA activity. Here we demonstrate that the expression of dead end 1 (Dnd1), an evolutionary conserved RNA-binding protein (RBP), counteracts the function of several miRNAs in human cells and in primordial germ cells of zebrafish by binding mRNAs and prohibiting miRNAs from associating with their target sites. These effects of Dnd1 are mediated through uridine-rich regions present in the miRNA-targeted mRNAs. Thus, our data unravel a novel role of Dnd1 in protecting certain mRNAs from miRNA-mediated repression.

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Sprache(n): eng - English
 Datum: 2007-12-28
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 330155
 Art des Abschluß: -

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Titel: Cell
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 131 Artikelnummer: - Start- / Endseite: 1273 - 1286 Identifikator: -