English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Stage of primary infection with lymphocytic choriomeningitis virus determines predisposition or resistance of mice to secondary bacterial infections

Gumenscheimer, M., Balkow, S., Simon, M. M., Jirillo, E., Galanos, C., & Freudenberg, M. A. (2007). Stage of primary infection with lymphocytic choriomeningitis virus determines predisposition or resistance of mice to secondary bacterial infections. Medical Microbiology and Immunology, 196, 79-88.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Gumenscheimer, Marina1, Author              
Balkow, Sandra1, Author              
Simon, Markus M.1, Author              
Jirillo, Emilio, Author
Galanos, Chris2, Author              
Freudenberg, Marina A.3, Author              
Affiliations:
1Metchnikoff Laboratory, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243654              
2Emeritus Group: Cellular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243649              
3Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              

Content

show
hide
Free keywords: LCMV-infection; Bacterial super-infection; LPS sensitivity
 Abstract: We investigated the effect of a primary non-lethal infection with lymphocytic choriomeningitis virus (LCMV) on the course and outcome of a secondary infection with the Gram-negative Salmonella enterica serovar Typhimurium or the Gram-positive Listeria monocytogenes in mice. We found that at each stage of the viral infection the susceptibility of mice to bacterial super-infections changes dramatically and depends also on whether the secondary infection is a Gram-positive or Gram-negative one. The study shows that the outcome of the secondary infection is determined by a delicate balance between the overproduction of and the hypersensitivity to inflammatory cytokines (TNF-α and IFN-γ), as well as by the changes in blood leukocytes occurring in mice in the course of viral infection.

Details

show
hide
Language(s): eng - English
 Dates: 2007
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 329594
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Medical Microbiology and Immunology
  Alternative Title : Med. Microbiol. Immunol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 196 Sequence Number: - Start / End Page: 79 - 88 Identifier: -