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  Lentivirus as a Tool for Lineage-Specific Gene Manipulations

Malashicheva, A., Kanzler, B., Tolkunova, E., Trono, D., & Tomilin, A. (2007). Lentivirus as a Tool for Lineage-Specific Gene Manipulations. Genesis, 45, 456-459.

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 Creators:
Malashicheva, Anna1, Author              
Kanzler, Benoît2, Author
Tolkunova, Elena1, Author              
Trono, Didier, Author
Tomilin, Alexey1, Author              
Affiliations:
1Department of Developmental Biology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243650              
2Max Planck Society, ou_persistent13              

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Free keywords: lentivirus vector; preimplantation development; gene delivery; mouse; placenta; trophoblast; tetrapoid aggregation
 Abstract: The trophectoderm (TE) of blastocysts, the first epithelium established in mammalian development, (1) plays signaling, supportive, and patterning functions during preimplantation development, (2) ensures embryo implantation into the uterine wall, and (3) gives rise to extraembryonic tissues essential for embryo patterning and growth after implantation. We show that mouse TE, itself permissive to lentiviral (LV) infection, represents a robust nonpermeable physical barrier to the virus particles, thereby shielding the cells of the inner cell mass from viral infection. This LV feature will allow modulations of gene expression in a lineage-specific manner, thus having significant applications in mouse functional genetics.

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Language(s): eng - English
 Dates: 2007
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 330259
 Degree: -

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Title: Genesis
Source Genre: Journal
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Pages: - Volume / Issue: 45 Sequence Number: - Start / End Page: 456 - 459 Identifier: -