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  Dynamics and interplay of nuclear architecture, genome organization, and gene expression

Schneider, R., & Grosschedl, R. (2007). Dynamics and interplay of nuclear architecture, genome organization, and gene expression. Genes and Development, 21, 3027-3043. doi:10.1101/gad.1604607.

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Schneider and Grosschedl 2007_Genes Dev.pdf (Publisher version), 545KB
 
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Schneider and Grosschedl 2007_Genes Dev.pdf
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http://genesdev.cshlp.org/content/21/23/3027 (Publisher version)
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 Creators:
Schneider, Robert1, Author              
Grosschedl, Rudolf2, Author              
Affiliations:
1Spemann Laboratory, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243655              
2Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

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Free keywords: Nuclear organization; chromatin; gene localization; chromsomal interactions
 Abstract: The organization of the genome in the nucleus of a eukaryotic cell is fairly complex and dynamic. Various features of the nuclear architecture, including compartmentalization of molecular machines and the spatial arrangement of genomic sequences, help to carry out and regulate nuclear processes, such as DNA replication, DNA repair, gene transcription, RNA processing, and mRNA transport. Compartmentalized multiprotein complexes undergo extensive modifications or exchange of protein subunits, allowing for an exquisite dynamics of structural components and functional processes of the nucleus. The architecture of the interphase nucleus is linked to the spatial arrangement of genes and gene clusters, the structure of chromatin, and the accessibility of regulatory DNA elements. In this review, we discuss recent studies that have provided exciting insight into the interplay between nuclear architecture, genome organization, and gene expression.

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Language(s): eng - English
 Dates: 2007-12-01
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1101/gad.1604607
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Title: Genes and Development
Source Genre: Journal
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Publ. Info: Cold Spring Harbor Laboratory Press
Pages: - Volume / Issue: 21 Sequence Number: - Start / End Page: 3027 - 3043 Identifier: ISSN: 0890-9369
CoNE: https://pure.mpg.de/cone/journals/resource/954925557453