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  Testing gene function early in the B cell lineage in mb 1-cre mice

Hobeika, E., Thiemann, S., Storch, B., Jumaa, H., Nielsen, P., Pelanda, R., et al. (2006). Testing gene function early in the B cell lineage in mb 1-cre mice. Proceedings of the National Academy of Sciences of the United States of America, 103, 13789-13794.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-9236-E Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-9237-C
Genre: Zeitschriftenartikel

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 Urheber:
Hobeika, E.1, Autor           
Thiemann, S., Autor
Storch, B.1, Autor           
Jumaa, H.1, Autor           
Nielsen, P.J.1, Autor           
Pelanda, R.1, Autor           
Reth, M.1, Autor           
Affiliations:
1Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243645              

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Schlagwörter: Dnmt1; SRp20; loxP; enhanced yellow fluorescent protein; lymphocyte
 Zusammenfassung: The mb1 gene encodes the Ig-α signaling subunit of the B cell antigen receptor and is expressed exclusively in B cells beginning at the very early pro-B cell stage in the bone marrow. We examine here the efficacy of the mb1 gene as a host locus for cre recombinase expression in B cells. We show that by integrating a humanized cre recombinase into the mb1 locus we obtain extraordinarily efficient recombination of loxP sites in the B cell lineage. The results from a variety of reporter genes including the splicing factor SRp20 and the DNA methylase Dnmt1 suggest that mb1-cre is probably the best model so far described for pan-B cell-specific cre expression. The availablity of a mouse line with efficient cre-mediated recombination at an early developmental stage in the B lineage provides an opportunity to study the role of various genes specifically in B cell development and function.

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Sprache(n): eng - English
 Datum: 2006-09-12
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 306577
 Art des Abschluß: -

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Titel: Proceedings of the National Academy of Sciences of the United States of America
  Alternativer Titel : PNAS
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 103 Artikelnummer: - Start- / Endseite: 13789 - 13794 Identifikator: -