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  Homeodomain-Mediated β-Catenin-Dependent Switching Events Dictate Cell-Lineage Determination

Olson, L. E., Tollkuhn, J., Scafoglio, C., Krones, A., Zhang, J., Ohgi, K. A., Wu, W., Taketo, M., Kemler, R., Grosschedl, R., Rose, D., & Li, X. (2006). Homeodomain-Mediated β-Catenin-Dependent Switching Events Dictate Cell-Lineage Determination. Cell, 125, 593-605. doi:10.1016/j.cell.2006.02.046.

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資料種別: 学術論文

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 作成者:
Olson, Lorin E.1, 著者
Tollkuhn, Jessica1, 著者
Scafoglio, Claudio1, 著者
Krones, Anna1, 著者
Zhang, Jie1, 著者
Ohgi, Kenneth A.1, 著者
Wu, Wei1, 著者
Taketo, Makoto1, 著者
Kemler, Rolf2, 著者           
Grosschedl, Rudolf3, 著者           
Rose, Dave1, 著者
Li, Xue1, 著者
所属:
1External Organizations, ou_persistent22              
2Emeritus Group: Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243656              
3Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

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キーワード: -
 要旨: While the biological roles of canonical Wnt/β-catenin signaling in development and disease are well documented, understanding the molecular logic underlying the functionally distinct nuclear transcriptional programs mediating the diverse functions of β-catenin remains a major challenge. Here, we report an unexpected strategy for β-catenin-dependent regulation of cell-lineage determination based on interactions between β-catenin and a specific homeodomain factor, Prop1, rather than Lef/Tcfs. β-catenin acts as a binary switch to simultaneously activate expression of the critical lineage-determining transcription factor, Pit1, and to repress the gene encoding the lineage-inhibiting transcription factor, Hesx1, acting via TLE/Reptin/HDAC1 coreprossor complexes. The strategy of functionally distinct actions of a homeodomain factor in response to Wnt signaling is suggested to be prototypic of a widely used mechanism for generating diverse cell types from pluripotent precursor cells in response to common signaling pathways during organogenesis.

資料詳細

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言語: eng - English
 日付: 2006-05-05
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子(DOI, ISBNなど): DOI: 10.1016/j.cell.2006.02.046
 学位: -

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出版物 1

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出版物名: Cell
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: Cambridge, Mass. : Cell Press
ページ: - 巻号: 125 通巻号: - 開始・終了ページ: 593 - 605 識別子(ISBN, ISSN, DOIなど): ISSN: 0092-8674
CoNE: https://pure.mpg.de/cone/journals/resource/954925463183