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  Co-evolution of a primordial peptide-presentation system and cellular immunity

Boehm, T. (2006). Co-evolution of a primordial peptide-presentation system and cellular immunity. Nature Reviews Immunology, 6, 79-84.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-926A-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-926B-7
Genre: Journal Article

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 Creators:
Boehm, Thomas1, Author              
Affiliations:
1Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              

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 Abstract: How did early vertebrates survive when their lymphocytes began to use antigen receptors with random specificities, despite their potential for extensive self-reactivity? Here, I propose that the quality-control mechanisms that tame self-reactivity in the adaptive immune system were derived, at least in part, from an ancient mechanism that guided sexual selection on the basis of evaluating genetic relatedness.

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Language(s): eng - English
 Dates: 2006-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 292672
 Degree: -

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Title: Nature Reviews Immunology
  Alternative Title : Nat. Rev. Immunol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 6 Sequence Number: - Start / End Page: 79 - 84 Identifier: -