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  Role of transcription factors in commitment and differentiation of early B lymphoid cells

Roessler, S., & Grosschedl, R. (2006). Role of transcription factors in commitment and differentiation of early B lymphoid cells. Seminars in Immunology, 18, 12-19. doi:10.1016/j.smim.2005.12.001.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-92AA-C Version Permalink: https://hdl.handle.net/21.11116/0000-0009-1D6A-1
Genre: Journal Article

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Roessler and Grosschedl 2006_Seminars Immunol.pdf (Publisher version), 251KB
 
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Roessler and Grosschedl 2006_Seminars Immunol.pdf
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https://www.sciencedirect.com/science/article/pii/S1044532305000965?via%3Dihub (Publisher version)
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 Creators:
Roessler, Stephanie1, Author           
Grosschedl, Rudolf1, Author           
Affiliations:
1Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

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 Abstract: B lymphopoiesis is a differentiation process in which hematopoietic stem cells are converted into antibody-producing plasma cells. B cell differentiation involves multiple steps, including cell specification, commitment to the B cell lineage, immunoglobulin rearrangements, maturation of B cells and terminal differentiation into plasma cells. Each of these steps is controlled by signaling pathways and transcription factors that act in synergy, feedback-loops or cross-antagonism to generate complex regulatory networks that allow for plasticity and stability of B cell differentiation.

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Language(s): eng - English
 Dates: 2006-02
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.smim.2005.12.001
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Title: Seminars in Immunology
Source Genre: Journal
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Publ. Info: London : Academic Press
Pages: - Volume / Issue: 18 Sequence Number: - Start / End Page: 12 - 19 Identifier: ISSN: 1044-5323
CoNE: https://pure.mpg.de/cone/journals/resource/954922650149