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  EBF2 Regulates Osteoblast-Dependent Differentiation of Osteoclasts

Kieslinger, M., Folberth, S., Dobreva, G., Dorn, T., Croci, L., Erben, R., et al. (2005). EBF2 Regulates Osteoblast-Dependent Differentiation of Osteoclasts. Developmental Cell, 9, 757-767. doi:10.1016/j.devcel.2005.10.009.

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Kieslinger 2005_Dev Cell.pdf (Publisher version), 868KB
 
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Kieslinger, Matthias1, Author              
Folberth, Stephanie1, Author              
Dobreva, Gergana1, Author              
Dorn, Tatjana2, Author
Croci, Laura2, Author
Erben, Reinhold2, Author
Consalez, G. Giacomo2, Author
Grosschedl, Rudolf1, Author              
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1Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              
2External Organizations, ou_persistent22              

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 Abstract: Communication between bone-depositing osteoblasts and bone-resorbing osteoclasts is required for bone development and homeostasis. Here, we identify EBF2, a member of the early B cell factor (EBF) family of transcription factors that is expressed in osteoblast progenitors, as a regulator of osteoclast differentiation. We find that mice homozygous for a targeted inactivation of Ebf2 show reduced bone mass and an increase in the number of osteoclasts. These defects are accompanied by a marked downregulation of the osteoprotegerin (Opg) gene, encoding a RANK decoy receptor. EBF2 binds to sequences in the Opg promoter and transactivates the Opg promoter in synergy with the Wnt-responsive LEF1/TCF:β-catenin pathway. Taken together, these data identify EBF2 as a regulator of RANK-RANKL signaling and osteoblast-dependent differentiation of osteoclasts.

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Language(s): eng - English
 Dates: 2005-12
 Publication Status: Published online
 Pages: -
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.devcel.2005.10.009
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Title: Developmental Cell
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 9 Sequence Number: - Start / End Page: 757 - 767 Identifier: ISSN: 1534-5807
CoNE: https://pure.mpg.de/cone/journals/resource/111006902714134