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  The t complex-encoded GTPase-activating protein Tagap1 acts as a transmission ratio distorter in mice

Bauer, H., Willert, J., Koschorz, B., & Herrmann, B. G. (2005). The t complex-encoded GTPase-activating protein Tagap1 acts as a transmission ratio distorter in mice. Nature Genetics, 37(9), 969-973.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-9313-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-9314-E
Genre: Journal Article

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 Creators:
Bauer, Hermann1, Author              
Willert, Jürgen, Author
Koschorz, Birgit2, Author              
Herrmann, Bernhard G.1, Author              
Affiliations:
1Department of Developmental Biology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243650              
2Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              

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 Abstract: Transmission ratio distortion in the mouse is caused by several t-complex distorters (Tcds) acting in trans on the t-complex responder (Tcr)1-4. Tcds additively affect the flagellar movement of all spermatozoa derived from t/+ males; sperm carrying Tcr are rescued, resulting in an advantage for t sperm in fertilization. Here we show that Tagap1, a GTPase-activating protein, can act as a distorter. Tagap1 maps to the Tcd1 interval and has four t loci, which encode altered proteins including a C-terminally truncated form. Overexpression of wild-type Tagap1 in sperm cells phenocopied Tcd function, whereas a loss-of-function Tagap1 allele reduced the transmission rate of the t6 haplotype. The combined data strongly suggest that the t loci of Tagap1 produce Tcd1a. Our results unravel the molecular nature of a Tcd and demonstrate the importance of small G proteins in transmission ratio distortion in the mouse.

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Language(s): eng - English
 Dates: 2005-09
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 250124
 Degree: -

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Title: Nature Genetics
Source Genre: Journal
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Pages: - Volume / Issue: 37 (9) Sequence Number: - Start / End Page: 969 - 973 Identifier: -