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  Requirement for TLR9 in the Immunomodulatory Activity of Propionibacterium acnes1

Kalis, C., Gumenscheimer, M., Freudenberg, N., Tchaptchet, S., Fejer, G., Heit, A., et al. (2005). Requirement for TLR9 in the Immunomodulatory Activity of Propionibacterium acnes1. The Journal of Immunology, 174, 4295-4300.

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 Creators:
Kalis, Christoph1, Author              
Gumenscheimer, Marina2, Author              
Freudenberg, Nikolaus, Author
Tchaptchet, Sandrine3, Author              
Fejer, György3, Author              
Heit, Antje2, Author              
Akira, Shizuo, Author
Galanos, Chris1, Author              
Freudenberg, Marina3, Author              
Affiliations:
1Emeritus Group: Cellular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243649              
2Metchnikoff Laboratory, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243654              
3Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              

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 Abstract: Propionibacterium acnes (formerly Corynebacterium parvum) is part of the human flora and, as such, is associated with several human pathologies. It possesses strong immunomodulatory activities, which makes this bacterium interesting for prophylactic and therapeutic vaccination. The bacterial component(s) and the host receptor(s) involved in the induction of these activities are poorly understood. We show in this study that TLR9 is crucial in generating the characteristic effects of killed P. acnes priming in the spleen, such as extramedullary hemopoiesis and organ enlargement, and granuloma formation in the liver. Furthermore, the ability to overproduce TNF-α and IFN-γ in response to LPS, lipid A, synthetic lipopeptide Pam3CysK4, or whole killed bacteria was present in P. acnes-primed wild-type, but not TLR9-/-, mice. Finally, P. acnes priming failed to induce enhanced resistance to murine typhoid fever in TLR9-/- mice. Thus, TLR9 plays an essential role in the induction of immunomodulatory effects by P. acnes. Because IFN-γ is a key mediator of these effects, and enhanced IFN-γ mRNA expression was absent in spleen and liver of P. acnes-primed TLR9-/- mice, we conclude that TLR9 is required for the induction of IFN-γ by P. acnes.

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Language(s): eng - English
 Dates: 2005
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: eDoc: 263184
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Title: The Journal of Immunology
Source Genre: Journal
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Pages: - Volume / Issue: 174 Sequence Number: - Start / End Page: 4295 - 4300 Identifier: -