Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme

Kutejova, E., Engist, B., Mallo, M., Kanzler, B., & Bobola, N. (2005). Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme. Development, 132, 469-478.

Item is

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Kutejova, Eva1, Autor           
Engist, Bettina2, Autor           
Mallo, Moisés, Autor
Kanzler, Benoît3, Autor
Bobola, Nicoletta1, Autor           
Affiliations:
1Department of Developmental Biology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243650              
2Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243644              
3Max Planck Society, ou_persistent13              

Inhalt

einblenden:
ausblenden:
Schlagwörter: Hoxa2, Six2, Hox genes, Branchial arches, Neural crest, Mouse
 Zusammenfassung: The Hoxa2 transcription factor acts during development of the second branchial arch. As for most of the developmental processes controlled by Hox proteins, the mechanism by which Hoxa2 regulates the morphology of second branchial arch derivatives is unclear. We show that Six2, another transcription factor, is genetically downstream of Hoxa2. High levels of Six2 are observed in the Hoxa2 loss-of-function mutant. By using a transgenic approach to overexpress Six2 in the embryonic area controlled by Hoxa2, we observed a phenotype that is reminiscent of the Hoxa2 mutant phenotype. Furthermore, we demonstrate that Hoxa2 regulation of Six2 is confined to a 0.9 kb fragment of the Six2 promoter and that Hoxa2 binds to this promoter region. These results strongly suggest that Six2 is a direct target of Hoxa2.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2005
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 263367
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Development
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 132 Artikelnummer: - Start- / Endseite: 469 - 478 Identifikator: -