English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Perp is required for tissue-specific cell survival during zebrafish development

Nowak, M., Köster, C., & Hammerschmidt, M. (2005). Perp is required for tissue-specific cell survival during zebrafish development. Cell Death and Differentiation, 12, 52-64.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Nowak, M.1, Author           
Köster, C.2, Author
Hammerschmidt, M.3, Author           
Affiliations:
1Spemann Laboratory, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243655              
2Max Planck Society, ou_persistent13              
3Georges Köhler Laboratory, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243653              

Content

show
hide
Free keywords: perp, p53, pmp22, apoptosis, cell survival, zebrafish, development
 Abstract: The tumor suppressor p53 has two alternative effects, causing either cell cycle arrest or apoptosis. The different effects are supposed to be mediated by the transcriptional activation of different target genes. perp, encoding a transmembrane protein of the Pmp22 family, is a transcriptional p53 target exclusively upregulated in apoptotic cells. However, its role during normal development had remained largely unclear. Here, we report the isolation and characterization of a zebrafish perp homolog. Upon overexpression in early zebrafish embryos, perp induces apoptosis. In addition, it contributes to p53-dependent und UV-induced cell death. However, during normal zebrafish development, perp displays a p53-independent and spatially restricted expression in specific cell types and tissues. Antisense-mediated loss of Perp function leads to increased apoptosis in perp-expressing cells of the developing skin and notochord. We conclude that, in contrast to its proapoptotic function in stressed cells, Perp plays an antiapoptotic role during normal zebrafish development to regulate tissue-specific cell survival.

Details

show
hide
Language(s): eng - English
 Dates: 2005
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 264962
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cell Death and Differentiation
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 12 Sequence Number: - Start / End Page: 52 - 64 Identifier: -