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  Wnt Signaling in Lymphopoiesis

Timm, A., & Grosschedl, R. (2005). Wnt Signaling in Lymphopoiesis. In H. Singh, R. Grosschedl, & Springer Science (Eds.), Molecular Analysis of B Lymphocyte Development and Activation (pp. 225-252). Berlin, Germany: Spring- Verlag.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-93F4-5 Version Permalink: https://hdl.handle.net/21.11116/0000-0009-1ED1-A
Genre: Book Chapter

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Locator:
https://link.springer.com/chapter/10.1007%2F3-540-26363-2_10 (Publisher version)
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 Creators:
Timm, A.1, Author
Grosschedl, R.2, Author           
Affiliations:
1External Organizations, ou_persistent22              
2Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

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 Abstract: Wnt signaling elicits changes in gene expression and cell physiology through β-catenin and LEF1/TCF proteins. The signal transduction pathway regulates many cellular and developmental processes, including cell proliferation, cell fate decisions and differentiation. In cells that have been stimulated by a Wnt protein, cytoplasmic β-catenin is stabilized and transferred to the nucleus, where it interacts with the nuclear mediators of Wnt signaling, the LEF1/TCF proteins, to elicit a transcriptional response. Loss-of-function and gain-of-function experiments in the mouse have provided insight into the role of this signaling pathway in lymphopoiesis. The self-renewal and maintenance of hematopoietic stem cells is regulated by Wnt signals. Differentiation of T cells and natural killer cells is blocked in the absence of LEF1/TCF proteins, and pro-B cell proliferation is regulated by Wnt signaling.

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Language(s): eng - English
 Dates: 2005
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/3-540-26363-2_10
 Degree: -

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Source 1

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Title: Molecular Analysis of B Lymphocyte Development and Activation
Source Genre: Book
 Creator(s):
Singh, Haringer, Editor
Grosschedl, Rudolf1, Editor           
Springer Science, Editor              
Affiliations:
1 Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641            
Publ. Info: Berlin, Germany : Spring- Verlag
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 225 - 252 Identifier: -

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Title: Current Topics of Microbiology and Immunology
Source Genre: Series
 Creator(s):
Compans, Editor
R.W., Editor
Cooper, Editor
M.D., Editor
Honjo, Editor
T., Editor
Melchers, Editor
F., Editor
Olsnes, Editor
S., Editor
Vogt, Editor
P.K., Editor
Springer Science, Editor              
Affiliations:
-
Publ. Info: -
Pages: - Volume / Issue: 290 Sequence Number: - Start / End Page: - Identifier: -