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  MHC Class I Peptide as Chemosensory Signals in the Vomeronasal Organ

Leinders-Zufall, T., Brennan, P., Widmayer, P., Chandramani S., P., Maul-Pavicic, A., Jäger, M., et al. (2004). MHC Class I Peptide as Chemosensory Signals in the Vomeronasal Organ. Science, 306, 1033-1037.

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 Creators:
Leinders-Zufall, Trese, Author
Brennan, Peter, Author
Widmayer, Patricia, Author
Chandramani S., Prashanth, Author
Maul-Pavicic, Andrea1, Author              
Jäger, Martina2, Author              
Li, Xiao-Hong, Author
Breer, Heinz, Author
Zufall, Frank, Author
Boehm, Thomas2, Author              
Affiliations:
1Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243645              
2Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              

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 Abstract: The mammalian vomeronasal organ detects social information about gender, status, and individuality. The molecular cues carrying this information remain largely unknown. Here, we show that small peptides that serve as ligands for major histocompatibility complex (MHC) class I molecules function also as sensory stimuli for a subset of vomeronasal sensory neurons located in the basal Gαo- and V2R receptor-express- ing zone of the vomeronasal epithelium. In behaving mice, the same peptides function as individuality signals underlying mate recognition in the context of pregnancy block. MHC peptides constitute a previously unknown family of chemosensory stimuli by which MHC genotypic diversity can influence social behavior.

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Language(s): eng - English
 Dates: 2004-11-05
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: eDoc: 211041
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Title: Science
Source Genre: Journal
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Pages: - Volume / Issue: 306 Sequence Number: - Start / End Page: 1033 - 1037 Identifier: -