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  MHC Class I Peptide as Chemosensory Signals in the Vomeronasal Organ

Leinders-Zufall, T., Brennan, P., Widmayer, P., Chandramani S., P., Maul-Pavicic, A., Jäger, M., et al. (2004). MHC Class I Peptide as Chemosensory Signals in the Vomeronasal Organ. Science, 306, 1033-1037. doi:10.1126/science.1102818.

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 Creators:
Leinders-Zufall, Trese1, Author
Brennan, Peter1, Author
Widmayer, Patricia1, Author
Chandramani S., Prashanth1, Author
Maul-Pavicic, Andrea1, Author           
Jäger, Martina2, Author           
Li, Xiao-Hong1, Author
Breer, Heinz1, Author
Zufall, Frank1, Author
Boehm, Thomas2, Author           
Affiliations:
1External Organizations, ou_persistent22              
2Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              

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 Abstract: The mammalian vomeronasal organ detects social information about gender, status, and individuality. The molecular cues carrying this information remain largely unknown. Here, we show that small peptides that serve as ligands for major histocompatibility complex (MHC) class I molecules function also as sensory stimuli for a subset of vomeronasal sensory neurons located in the basal Gαo- and V2R receptor-express- ing zone of the vomeronasal epithelium. In behaving mice, the same peptides function as individuality signals underlying mate recognition in the context of pregnancy block. MHC peptides constitute a previously unknown family of chemosensory stimuli by which MHC genotypic diversity can influence social behavior.

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Language(s): eng - English
 Dates: 2004-11-05
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1126/science.1102818
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Title: Science
  Abbreviation : Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 306 Sequence Number: - Start / End Page: 1033 - 1037 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1