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  Chemokine Gene Expression in Toll-Like Receptor-Competent and -Deficient Mice Infected with Leishmania major.

Antoniazi, S., Price, H. P., Kropf, P., Freudenberg, M. A., Galanos, C., Smith, D. F., et al. (2004). Chemokine Gene Expression in Toll-Like Receptor-Competent and -Deficient Mice Infected with Leishmania major. Infection and Immunity, 72(9), 5168-5174.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-942D-0 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-942E-E
Genre: Journal Article

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 Creators:
Antoniazi, Simone, Author
Price, Helen P., Author
Kropf, Pascale, Author
Freudenberg, Marina A.1, Author           
Galanos, Chris2, Author           
Smith, Deborah F., Author
Müller, Ingrid, Author
Affiliations:
1Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              
2Emeritus Group: Cellular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243649              

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 Abstract: We studied the expression of a subset of chemokines, including RANTES/CCL5, MIP-1α/CCL3, IP-10/CXCL10, and MCP-1/CCL2, in Toll-like receptor (TLR)-competent and -deficient mice after infection with Leishmania major. Chemokine expression at the site of infection (the footpad), in the draining lymph nodes and in the spleens of infected animals was determined by using two different methods of analysis. The results indicate that L. major infection causes overall upregulation of RANTES/CCL5, MIP-1α/CCL3, IP-10/CXCL10, and MCP-1/CCL2 in the footpads and lymph nodes, while expression of these chemokines is constitutive in the spleens of TLR4-competent mice (C57BL/10ScSn) and TLR4-deficient mice (C57BL10/ScN). Different patterns of expression were detected depending on the time postinfection, but there was little variation in the expression of these four chemokines in the presence or absence of TLR4.

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Language(s): eng - English
 Dates: 2004-09
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 206809
 Degree: -

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Title: Infection and Immunity
Source Genre: Journal
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Pages: - Volume / Issue: 72 (9) Sequence Number: - Start / End Page: 5168 - 5174 Identifier: -