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  LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis

Galceran, J., Sustmann, C., Hsu, S.-C., Folberth, S., & Grosschedl, R. (2004). LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes and Development, 18, 2718-2723. doi:10.1101/gad.1249504.

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Galceran 2004_Genes Dev.pdf (Publisher version), 238KB
 
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http://genesdev.cshlp.org/content/18/22/2718 (Publisher version)
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 Creators:
Galceran, Juan1, Author
Sustmann, Claudio2, Author              
Hsu, Shu-Chi2, Author              
Folberth, Stephanie2, Author              
Grosschedl, Rudolf2, Author              
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1External Organizations, ou_persistent22              
2Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

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Free keywords: Simitogenesis; LEF1/TCF; Wnt; Notch; Dll1
 Abstract: Wnt signaling, which is mediated by LEF1/TCF transcription factors, has been placed upstream of the Notch pathway in vertebrate somitogenesis. Here, we examine the molecular basis for this presumed hierarchy and show that a targeted mutation of Lef1, which abrogates LEF1 function and impairs the activity of coexpressed TCF factors, affects the patterning of somites and the expression of components of the Notch pathway. LEF1 was found to bind multiple sites in the Dll1 promoter in vitro and in vivo. Moreover, mutations of LEF1-binding sites in the Dll1 promoter impair expression of a Dll1-LacZ transgene in the presomitic mesoderm. Finally, the induced expression of LEF1-β-catenin activates the expression of endogenous Dll1 in fibroblastic cells. Thus, Wnt signaling can affect the Notch pathway by a LEF1-mediated regulation of Dll1.

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Language(s): eng - English
 Dates: 2004-11-15
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1101/gad.1249504
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Title: Genes and Development
Source Genre: Journal
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Publ. Info: Cold Spring Harbor Laboratory Press
Pages: - Volume / Issue: 18 Sequence Number: - Start / End Page: 2718 - 2723 Identifier: ISSN: 0890-9369
CoNE: https://pure.mpg.de/cone/journals/resource/954925557453