Molecular Recognition of Haptens by T Cells: More Than One Way to Tickle the 
Receptor

Weltzien, Hans-Ulrich; Dötze, Andrea; Gamerdinger, Katharina; Hellwig, Sven; Thierse, Hermann-Josef

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Molecular Recognition of Haptens by T Cells: More Than One Way to Tickle the Receptor

Weltzien, H.-U., Dötze, A., Gamerdinger, K., Hellwig, S., & Thierse, H.-J. (2004). Molecular Recognition of Haptens by T Cells: More Than One Way to Tickle the Receptor. Georgetown, USA: Landes Bioscience.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-94A7-D Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-94A8-B

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Urheber:
Weltzien, Hans-Ulrich¹, Autor
Dötze, Andrea², Autor
Gamerdinger, Katharina¹, Autor
Hellwig, Sven², Autor
Thierse, Hermann-Josef³, Autor

Affiliations:
1Emeritus Group: Cellular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243649
2Max Planck Society, ou_persistent13
3Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243645

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Zusammenfassung: Haptens as low molecular chemicals compose a major percentage of the universe of allergens, particularly with respect to allergic contact dermatitis (ACD). They are usually defined as compounds which only upon covalent interaction with proteins acquire the potential to induce hapten-specific B cell as well as T cell responses. Here we discuss recent developments in the basic understanding of MHC-restricted recognition of haptens by αβ T cells. Major emphasis is put on the structural elucidation of MHC-restricted epitopes for the model hapten TNP as well as for nickel as a major human contact sensitizer. Furthermore, we show that in addition to forming allergenic determinants penicillin and nickel can interact with the immunologically relevant molecules interferon gamma (IFN-γ) and heatshock proteins, respectively. Also taking into account that coordination complexes of metal ions as well as certain drugs may be recognized by T cells in noncovalent MHC association, the definition and functions of haptens may have to be reevaluated.