Differential Contribution of Toll-Like Receptors 4 and 2 to the Cytokine 
Response to Salmonella enterica Serovar Typhimurium and Staphylococcus aureus 
in Mice

Lembo, Annalisa; Kalis, Christoph; Kirschning, Carsten J.; Mitolo, Vincenzo; Jirillo, Emilio; Wagner, Hermann; Galanos, Chris; Freudenberg, Marina A.

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Differential Contribution of Toll-Like Receptors 4 and 2 to the Cytokine Response to Salmonella enterica Serovar Typhimurium and Staphylococcus aureus in Mice

Lembo, A., Kalis, C., Kirschning, C. J., Mitolo, V., Jirillo, E., Wagner, H., et al. (2003). Differential Contribution of Toll-Like Receptors 4 and 2 to the Cytokine Response to Salmonella enterica Serovar Typhimurium and Staphylococcus aureus in Mice. Infection and Immunity, 71(10), 6058-6062.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-94F5-C Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-94F6-A

Genre: Journal Article

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Creators:
Lembo, Annalisa¹, Author
Kalis, Christoph¹, Author
Kirschning, Carsten J., Author
Mitolo, Vincenzo, Author
Jirillo, Emilio, Author
Wagner, Hermann, Author
Galanos, Chris¹, Author
Freudenberg, Marina A.², Author

Affiliations:
1Emeritus Group: Cellular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243649
2Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647

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Abstract: The contribution of murine Toll-like receptors 2 and 4 (TLR2 and -4, respectively) to cytokine induction by heat-killed bacteria was analyzed in vitro and in vivo. Gram-negative bacteria induced cytokines primarily via TLR4; the contribution of TLR2 was only minor. Neither TLR4 nor, surprisingly, TLR2 was required in the MyD88-dependent response to Staphylococcus aureus.

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Language(s): eng - English

Dates: Date issued: 2003-10

Publication Status: Issued

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Identifiers: eDoc: 126429
ISI: 000185551200070

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Title: Infection and Immunity

Alternative Title : Infect. Immun.

Source Genre: Journal

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Pages: - Volume / Issue: 71 (10) Sequence Number: - Start / End Page: 6058 - 6062 Identifier: ISSN: 0019-9567