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  Essential role of Src-family protein tyrosine kinases in NF- κB activation during B cell development

Saijo, K., Schmedt, C., Su, I.-h., Karasuyama, H., Lowell, C. A., Reth, M., et al. (2003). Essential role of Src-family protein tyrosine kinases in NF- κB activation during B cell development. Nature Immunology, 4(3), 274-279.

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 Creators:
Saijo, Kaoru, Author
Schmedt, Christian, Author
Su, I-hsin, Author
Karasuyama, Hajime, Author
Lowell, Clifford A., Author
Reth, Michael1, Author              
Adachi, Takahiro1, Author              
Patke, Alina, Author
Santana, Angela, Author
Tarakhovsky, Alexander, Author
Affiliations:
1Research Group and Chair of Molecular Immunology of the University of Freiburg, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243645              

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 Abstract: The nature of signals that govern the development of immunoglobulin heavy chain-dependent B cells is largely unknown. Using mice deficient for the B cell-expressed Src- family protein tyrosine kinases (SFKs) Blk, Fyn and Lyn, we show an essential role of these kinases in pre-B cell receptor (pre-BCR)-mediated NF-κB activation and B cell development. This signaling defect is SFK specific, as a deficiency in Syk, which controls pre-B cell development, does not affect NF-κB induction. Impaired NF-κB induction was overcome by the activation of protein kinase C (PKC)-λ, thus suggesting the involvement of PKC-λ in pre-BCR-mediated SFK-dependent activation of NF-κB. Our data show the existence of a functionally distinct SFK signaling module responsible for pre-BCR-mediated NF-κB activation and B cell development.

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Language(s): eng - English
 Dates: 2003-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 28953
ISI: 000181201000017
 Degree: -

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Title: Nature Immunology
  Alternative Title : Nat. Immunol.
Source Genre: Journal
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Pages: - Volume / Issue: 4 (3) Sequence Number: - Start / End Page: 274 - 279 Identifier: ISSN: 1529-2908