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  Differential Expression and Regional Distribution of Individual Gamma-protocadherin Transcripts in the Central Nervous System of the Mouse

Ebert, M., Kemler, R., & Frank, M. (2003). Differential Expression and Regional Distribution of Individual Gamma-protocadherin Transcripts in the Central Nervous System of the Mouse. European Journal of Cell Biology, 82(Suppl. 53), 22-23.

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 Creators:
Ebert, Matthias1, Author           
Kemler, Rolf1, Author           
Frank, Marcus2, Author           
Affiliations:
1Emeritus Group: Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243656              
2Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243651              

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 Abstract: Three clusters of protocadherin genes (alpha, beta, gamma PCDHs) are present in the human and mouse genome. In both, gamma PCDHs comprise 22 family members in three groups (A, B, C). We detected transcripts of individual gamma PCDHs in many neurons of the developing and adult mouse brain by in situ hybridization and Northern blots. Highest expression is generally found in forebrain, hippocampus and cerebellum during the second postnatal week. Both regional and cellular differences are observed for the examined transcripts (gamma A1, A12, B4, C3, C5). Temporally, C5 shows a later onset, distinct from the other gamma PCDHs. Our findings suggest that subtypes of neurons express a defined pattern of individual gamma PCDH genes.

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Language(s): eng - English
 Dates: 2003-03
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 125020
ISI: 000182016200004
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Title: European Journal of Cell Biology
  Alternative Title : Eur. J. Cell Biol.
Source Genre: Journal
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Pages: - Volume / Issue: 82 (Suppl. 53) Sequence Number: - Start / End Page: 22 - 23 Identifier: ISSN: 0171-9335