English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  The ankyrin repeat protein Diversin recruits Casein kinase Iε to the β-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling

Schwarz-Romond, T., Asbrand, C., Bakkers, J., Kuehl, M., Schaeffer, H.-J., Huelsken, J., et al. (2002). The ankyrin repeat protein Diversin recruits Casein kinase Iε to the β-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes & Development, 16(16), 2073-2084.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Schwarz-Romond, Thomas, Author
Asbrand, Christian, Author
Bakkers, Jeroen1, Author           
Kuehl, Michael, Author
Schaeffer, Hans-Joerg, Author
Huelsken, Joerg, Author
Behrens, Juergen, Author
Hammerschmidt, Matthias1, Author           
Birchmeier, Walter, Author
Affiliations:
1Georges Köhler Laboratory, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243653              

Content

show
hide
Free keywords: Signal transduction; embryonic axis formation; planar cell polarity; axin/conductin; Diego
 Abstract: Wnt signals control decisive steps in development and can induce the formation of tumors. Canonical Wnt signals control the formation of the embryonic axis, and are mediated by stabilization and interaction of beta-catenin with Lef/Tcf transcription factors. An alternative branch of the Wnt pathway uses JNK to establish planar cell polarity in Drosophila and gastrulation movements in vertebrates. We describe here the vertebrate protein Diversin that interacts with two components of the canonical Wnt pathway, Casein kinase Iε (CKIε) and Axin/Conductin. Diversin recruits CKIε to the β-catenin degradation complex that consists of Axin/Conductin and GSK3β and allows efficient phosphorylation of β-catenin, thereby inhibiting β-catenin/Tcf signals. Morpholino-based gene ablation in zebrafish shows that Diversin is crucial for axis formation, which depends on β-catenin signaling. Diversin is also involved in JNK activation and gastrulation movements in zebrafish. Diversin is distantly related to Diego of Drosophila, which functions only in the pathway that controls planar cell polarity. Our data show that Diversin is an essential component of the Wnt-signaling pathway and acts as a molecular switch, which suppresses Wnt signals mediated by the canonical β-catenin pathway and stimulates signaling via JNK.

Details

show
hide
Language(s): eng - English
 Dates: 2002-08-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 28279
ISI: 000177517100004
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Genes & Development
  Alternative Title : Genes Dev.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 16 (16) Sequence Number: - Start / End Page: 2073 - 2084 Identifier: ISSN: 0890-9369