English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The Course of Leishmania Major Infection in Mice Lacking Granzyme-Mediated Mechanisms

Eisert, V., Muenster, U., Simon, M. M., & Moll, H. (2002). The Course of Leishmania Major Infection in Mice Lacking Granzyme-Mediated Mechanisms. Immunobiology, 205(3), 314-320.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Eisert, Veronika, Author
Muenster, Uwe, Author
Simon, Markus M.1, Author              
Moll, Heidrun, Author
Affiliations:
1Metchnikoff Laboratory, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243654              

Content

show
hide
Free keywords: -
 Abstract: We previously showed that T cells expressing granzyme (Urn) A are more frequent in skin lesions of susceptible mice than in those of resistant mice infected with the intracellular parasite Leishmania major. To determine the in viva role of gum in cutaneous leishmaniasis, we examined the course of L major infection in gzmA-deficient mice. Despite a delay in host colonization of susceptible mice, the lack of gzmA did not influence the curse of lesion development or result in a discernible iteration of the interferon-γ and interleukin-4 production. Moreover, no differences in these parameters were observed between wild-type controls and mice deficient in gzmB or both gzmA and gzmB. These findings indicate that neither gzmA nor gzmB are critical for the development of T helper cell responses and the outcome of L. major infection.

Details

show
hide
Language(s): eng - English
 Dates: 2002-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 28988
ISI: 000177340800010
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Immunobiology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 205 (3) Sequence Number: - Start / End Page: 314 - 320 Identifier: ISSN: 0171-2985