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  Testosterone signaling in T cells and macrophages

Wunderlich, F., Benten, W. P. M., Lieberherr, M., Guo, Z. Y., Stamm, O., Wrehlke, C., et al. (2002). Testosterone signaling in T cells and macrophages. Steroids, 67(6), 535-538.

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 Creators:
Wunderlich, Frank, Author
Benten, W. P. M., Author
Lieberherr, Michèle, Author
Guo, Zhiyong Y., Author
Stamm, Olaf, Author
Wrehlke, Christian, Author
Sekeris, Constantin E., Author
Mossmann, Horst1, Author           
Affiliations:
1Emeritus Group: Cellular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243649              

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Free keywords: Testosterone; Non-genomic signaling; Surface receptors; Malaria; T cells; Macrophages
 Abstract: This review summarizes data about non-genomic actions of testosterone on murine malaria, T cells and macrophages produced by our group during the last 15 years. In C578L/10 mice, testosterone induces a lethal outcome of blood stage infections with Plasmodium chabaudi which normally takes a self-healing course controlled by genes of the H-2 complex and the non-H-2 background. This suppressive effect of testosterone is mediated neither via the classic intracellular androgen receptor (AR) response nor, after conversion of testosterone to estradiol, via the estrogen receptor. Testosterone acts non-genomically, i.e. through surface receptors, on murine T cells and macrophages, which becomes evident as a rapid rise in the intracellular free Ca<sup>₂₊</sup> concentration ([Ca<sup>₂₊</sup>]<sub>i</sup>). In T cells, this rise reflects predominantly influx of extracellular Ca<sup>₂₊</sup>, while it is predominantly due to release of Ca<sup>₂₊</sup> from intracellular Ca<sup>₂₊</sup>-stores in macrophages. The testosterone- induced rise in [Ca<sup>₂₊</sup>]<sub>i</sup>) of both macrophages and T cells is not inhibited by the AR-blocker cyproterone, and it is also inducible by the plasma membrane impermeable ligand testosterone-BSA. The surface receptors initiate a transcription-independent signaling pathway of testosterone. Currently, we are trying to isolate testosterone surface receptors and to investigate a possible cross-talk of non-genomic testosterone signaling with other genotropic signaling pathways.

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Language(s): eng - English
 Dates: 2002-05
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 28946
ISI: 000175306300018
 Degree: -

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Title: Steroids
Source Genre: Journal
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Affiliations:
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Pages: - Volume / Issue: 67 (6) Sequence Number: - Start / End Page: 535 - 538 Identifier: ISSN: 0039-128X