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  Thymopoiesis requires Pax9 function in thymic epithelial cells

Hetzer-Egger, C., Schorpp, M., Haas-Assenbaum, A., Balling, R., Peters, H., & Boehm, T. (2002). Thymopoiesis requires Pax9 function in thymic epithelial cells. European Journal of Immunology, 32(4), 1175-1181. doi:10.1002/1521-4141(200204)32:4<1175:AID-IMMU1175>3.0.CO;2-U.

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 Creators:
Hetzer-Egger, Claudia1, Author           
Schorpp, Michael1, Author           
Haas-Assenbaum, Annette1, Author           
Balling, Rudi, Author
Peters, Heiko, Author
Boehm, Thomas1, Author           
Affiliations:
1Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              

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Free keywords: Thymus; Development; Pax9; Mutant mouse; Apoptosis
 Abstract: The epithelial thymic anlage develops from the third pharyngeal pouch. Pax9 is expressed in the entire pharyngeal endoderm, and its function is required for normal development of organs derived from pharyngeal pouches. Here, we show that in Pax9 null mice, the thymic anlage develops as an ectopic polyp-like structure in the larynx. It expresses Whn/Foxn1, a marker of thymic epithelium, but fails to perform the normal caudo-ventral movement to the upper mediastinum. The thymic rudiment contains mesenchymal cells, blood vessels and is colonized by T cell progenitors. However, from embryonic day 14.5 onwards, the size of the Pax9 mutant thymus is severely reduced. Whereas expression of TCRβ chain genes is readily detectable in the mutant thymus, no expression of the TCRγ chain was detectable. Our results identify a new genetically defined control point of thymopoiesis.

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Language(s): eng - English
 Dates: 2002-03-25
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: European Journal of Immunology
  Other : Eur. J. Immunol.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 32 (4) Sequence Number: - Start / End Page: 1175 - 1181 Identifier: ISSN: 0014-2980
CoNE: https://pure.mpg.de/cone/journals/resource/954925398487