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  Abnormal bone marrow stroma in mice deficient for nemo-like kinase, Nlk

Kortenjann, M., Nehls, M., Smith, A. J. H., Carsetti, R., Schueler, J., Koehler, G., et al. (2001). Abnormal bone marrow stroma in mice deficient for nemo-like kinase, Nlk. European Journal of Immunology, 31(12), 3580-3587. doi:10.1002/1521-4141(200112)31:12<3580:aid-immu3580>3.0.co;2-n.

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 Creators:
Kortenjann, Monika1, Author              
Nehls, Michael2, Author
Smith, Andrew J. H.2, Author
Carsetti, Rita1, Author              
Schueler, Julia1, Author
Koehler, Gabriele2, Author
Boehm, Thomas1, Author              
Affiliations:
1Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              
2External Organizations, ou_persistent22              

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Free keywords: Bone marrow; Stroma; Lymphopenia; MAP kinase; Mesenchymal stem cell
 Abstract: The stromal compartment of the bone marrow is composed of various cell types that provide trophic and instructive signals for hematopoiesis. The mesenchymal stem cell is believed to give rise to all major cellular components of the bone marrow microenvironment. Nemo-like kinase, Nlk, is a serine-threonine kinase that connects MAP kinase and Wnt signaling pathways; its in vivo function in mouse is unknown. We have generated mice with a targeted disruption of Nlk and find that the complex phenotype significantly varies with the genetic background. Whereas C57BL/6 mice lacking Nlk die during the third trimester of pregnancy, the 129/Sv background supports survival into adolescence; such mice are growth retarded and suffer from various neurological abnormalities. We show here that the Nlk deficiency syndrome includes aberrant differentiation of bone marrow stromal cells. Varying degrees of morphological abnormality, such as increased numbers of adipocytes, large blood sinuses and absence of bone-lining cells are observed in the bone marrow of mutant mice. Nlk deficient mice thus provide a novel model to study the genetic requirements for bone marrow stromal differentiation.

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Language(s): eng - English
 Dates: 2001-12
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: European Journal of Immunology
  Other : Eur. J. Immunol.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 31 (12) Sequence Number: - Start / End Page: 3580 - 3587 Identifier: ISSN: 0014-2980
CoNE: https://pure.mpg.de/cone/journals/resource/954925398487