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  Expression domains in the skin of genes affected by the nude mutation and identified by gene expression profiling

Schlake, T., & Boehm, T. (2001). Expression domains in the skin of genes affected by the nude mutation and identified by gene expression profiling. Mechanisms of Development, 109(2), 419-422. doi:10.1016/s0925-4773(01)00538-x.

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 Creators:
Schlake, Thomas1, Author              
Boehm, Thomas1, Author              
Affiliations:
1Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              

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Free keywords: Whn; Nude; Skin; Hair follicle; Differentiation
 Abstract: Although several genes affected by the nude mutation inactivating the transcription factor Whn have recently been identified, a comprehensive molecular analysis of the nude phenotype is still missing. Gone expression profiling of wildtype and nude mice back skin reveals several so far unknown differences in mRNA levels and demonstrates that microarray hybridization is ideal to identify even quantitative changes in expression. Some genes are upregulated in the absence of Whn. Most of the differentially expressed genes are downregulated in nude skin. Our results identify metallothionein IV among these genes. This is the first report on metallothionein IV expression in the murine hair follicle; its expression domain almost completely overlaps that of Whn.

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Language(s): eng - English
 Dates: 2001-12
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Mechanisms of Development
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Shannon : Elsevier
Pages: - Volume / Issue: 109 (2) Sequence Number: - Start / End Page: 419 - 422 Identifier: ISSN: 0925-4773
CoNE: https://pure.mpg.de/cone/journals/resource/954927703126