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  Differential clearance and induction of host responses by various administered or released lipopolysaccharides

Hasunuma, R., Morita, H., Tanaka, S., Ryll, R., Freudenberg, M. A., Galanos, C., et al. (2001). Differential clearance and induction of host responses by various administered or released lipopolysaccharides. Journal of Endotoxin Research, 7(6), 421-429.

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 Urheber:
Hasunuma, Ryoichi, Autor
Morita, Hiroyuki, Autor
Tanaka, Shigenori, Autor
Ryll, Roland, Autor
Freudenberg, Marina A.1, Autor           
Galanos, Chris2, Autor           
Kumazawa, Yoshio, Autor
Affiliations:
1Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              
2Emeritus Group: Cellular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243649              

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 Zusammenfassung: The clearance and activity of different types of lipopolysaccharide (LPS) released during infection with Gram- negative bacteria were investigated. When highly purified preparations differing in their specific endotoxin activity were administered intravenously to mice, the clearance of rough (R)-form LPS preparations from Salmonella minnesota and Escherichia coli was much faster than that of a smooth (S)-form LPS preparation from Salmonella abortus equi, but slower than that of lipooligosaccharides (LOS) preparations from Bordetella pertussis and Helicobacter pylori. After intraperitoneal infection with 10 and 10 CFU E. coli O111:B4, relatively high levels of LPS were detected dose-dependently in the plasma of infected mice and persisted for a long time. In addition, plasma sCD14 levels in infected mice were higher than in LPS-administered mice. These results indicate that continuously higher levels of plasma LPS followed by stronger host responses occur during infection and suggest that these differences between LPS-administered and infected mice should be taken into consideration when analyzing host responses induced by LPS.

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Sprache(n): eng - English
 Datum: 2001
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 18565
ISI: 000173090700002
 Art des Abschluß: -

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Titel: Journal of Endotoxin Research
  Alternativer Titel : J. Endoxtin Res.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 7 (6) Artikelnummer: - Start- / Endseite: 421 - 429 Identifikator: ISSN: 0968-0519