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Schlagwörter:
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Zusammenfassung:
Many aspects of modern material science and biology rely on the strategic manipulation and understanding
of polymer dynamics in confining micro- and nanoflow. We directly observe and analyze nonequilibrium structural and dynamic properties of individual semiflexible actin filaments in pressure-driven microfluidic channel flow using fluorescence microscopy. Different conformational shapes, such as filaments fluctuating in an elongated manner, parabolically bent, as well
as tumbling, are identified. With increasing flow velocity, a strong center-of-mass migration toward the channel walls is
observed. This significant migration effect can be explained by a shear rate dependent spatial diffusivity due to a gradient in chain
mobility of the semiflexible polymers.
