English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Situating the default-mode network in a principal gradient of macroscale cortical organization

Margulies, D. S., Ghosh, S. S., Goulas, A., Falkiewicz, M., Huntenburg, J. M., Langs, G., et al. (2016). Situating the default-mode network in a principal gradient of macroscale cortical organization. Proceedings of the National Academy of Sciences of the United States of America, 113(44), 12574-12579. doi:10.1073/pnas.1608282113.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-7A9E-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-1C19-3
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Margulies, Daniel S.1, Author              
Ghosh, Satrajit S.2, Author
Goulas, Alexandros2, Author              
Falkiewicz, Marcel1, Author              
Huntenburg, Julia M.1, Author              
Langs, Georg2, Author
Bezgin, Gleb2, Author
Eickhoff, Simon2, Author
Castellanos, F. Xavier 2, Author
Petrides, Michael2, Author
Jefferies, Elizabeth2, Author
Smallwood, Jonathan2, Author
Affiliations:
1Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              
2External Organizations, ou_persistent22              

Content

show
hide
Free keywords: Topography; Connectivity; Cortical organization; Default-mode network
 Abstract: Understanding how the structure of cognition arises from the to- pographical organization of the cortex is a primary goal in neuroscience. Previous work has described local functional gradients extending from perceptual and motor regions to cortical areas representing more abstract functions, yet an overarching framework for the association between structure and function is still lacking. Here we show that the principal gradient revealed by the decomposition of connectivity data in humans and the macaque monkey is anchored, at one end, by regions serving primary sensory/motor functions and, at the other, by transmodal regions that, in humans, are known as the default-mode network (DMN). These DMN regions exhibit the greatest geodesic distance along the cortical surface — and are precisely equidistant — from primary sensory/motor morphological landmarks. The principal gradient also provides an organizing spatial framework for multiple large-scale networks and characterizes a spectrum from unimodal to heteromodal activity in a functional meta-analysis. Together these observations provide a novel characterization of the topographical organization of cortex and indicate that the role of the DMN in cognition might arise from its position at one extreme of a hierarchy, allowing it to process transmodal information that is unrelated to immediate sensory input.

Details

show
hide
Language(s): eng - English
 Dates: 2016-05-272016-09-092016-11-012016-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1073/pnas.1608282113
PMID: 27791099
PMC: PMC5098630
Other: Epub 2016
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Proceedings of the National Academy of Sciences of the United States of America
  Abbreviation : PNAS
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 113 (44) Sequence Number: - Start / End Page: 12574 - 12579 Identifier: ISSN: 0027-8424
CoNE: /journals/resource/954925427230