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  Situating the default-mode network in a principal gradient of macroscale cortical organization

Margulies, D. S., Ghosh, S. S., Goulas, A., Falkiewicz, M., Huntenburg, J. M., Langs, G., et al. (2016). Situating the default-mode network in a principal gradient of macroscale cortical organization. Proceedings of the National Academy of Sciences of the United States of America, 113(44), 12574-12579. doi:10.1073/pnas.1608282113.

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https://doi.org/10.1073/pnas.1608282113 (Publisher version)
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 Creators:
Margulies, Daniel S.1, Author           
Ghosh, Satrajit S.2, Author
Goulas, Alexandros2, Author           
Falkiewicz, Marcel1, Author           
Huntenburg, Julia M.1, Author           
Langs, Georg2, Author
Bezgin, Gleb2, Author
Eickhoff, Simon2, Author
Castellanos, F. Xavier 2, Author
Petrides, Michael2, Author
Jefferies, Elizabeth2, Author
Smallwood, Jonathan2, Author
Affiliations:
1Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              
2External Organizations, ou_persistent22              

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Free keywords: Topography; Connectivity; Cortical organization; Default-mode network
 Abstract: Understanding how the structure of cognition arises from the to-
pographical organization of the cortex is a primary goal in neuroscience. Previous work has described local functional gradients extending from perceptual and motor regions to cortical areas representing more abstract functions, yet an overarching framework for the association between structure and function is still lacking. Here we show that the principal gradient revealed by the decomposition of connectivity data in humans and the macaque monkey is anchored, at one end, by regions serving primary sensory/motor functions and, at the other, by transmodal regions that, in humans, are known as the default-mode network (DMN). These DMN regions exhibit the greatest geodesic distance along the cortical surface — and are precisely equidistant — from primary sensory/motor morphological landmarks. The principal gradient also provides an organizing spatial framework for multiple large-scale networks and characterizes a spectrum from unimodal to heteromodal activity in a functional meta-analysis. Together these observations provide a novel characterization of the topographical organization of cortex and indicate that the role of the DMN in cognition might arise from its position at one extreme of a hierarchy, allowing it to process transmodal information that is unrelated to immediate sensory input.

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Language(s): eng - English
 Dates: 2016-05-272016-09-092016-11-012016-11
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1073/pnas.1608282113
PMID: 27791099
PMC: PMC5098630
Other: Epub 2016
 Degree: -

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Funding organization : Fonds zur Förderung wissenschaftlicher Forschung
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Funding organization : Helmholtz Portfolio Theme
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Grant ID : P41EB015902
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Funding organization : NIH National Institute of Biomedical Imaging and Bioengineering Neuroimaging Analysis Center
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Grant ID : 1U54MH091657
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Funding organization : Oxford University Consortium
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Funding organization : National Institutes of Health (NIH)
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Grant ID : R01-MH074457
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Funding organization : National Institute of Mental Health (NIMH)
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Grant ID : R01NS086905
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Funding organization : National Institute of Neurological Disorders and Stroke (NINDS)
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Grant ID : R01EB020740
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Funding organization : National Institute of Biomedical Imaging and Bioengineering (NIBIB)
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Funding organization : NIH Blueprint for Neuroscience Research
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Funding organization : John Templeton Foundation (JTF)
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Funding organization : University of Minnesota (UMN)
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Funding organization : University of Washington (UW)
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Grant ID : 1P41EB019936-01A1, 1R01EB020740-01A1, 1U01MH108168-01, 3R01MH092380-04S2
Funding program : -
Funding organization : McDonnell Center for Systems Neuroscience
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Grant ID : 283530, 646927
Funding program : Horizon 2020 Framework Programme (H2020)
Funding organization : European Union (EU)
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Grant ID : 604102
Funding program : Seventh Framework Programme (FP7)
Funding organization : European Commission (EC)
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Grant ID : FDN-143212
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Funding organization : Canadian Institutes of Health Research (IRSC)
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Grant ID : BB/J006963/1
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Funding organization : Biotechnology and Biological Sciences Research Council (BBSRC)
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Grant ID : I2714-B31, KLI 544- B27
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Funding organization : Austrian Science Fund (FWF)
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Grant ID : 15356
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Funding organization : Oesterreichische Nationalbank (OeNB)

Source 1

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Title: Proceedings of the National Academy of Sciences of the United States of America
  Abbreviation : PNAS
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 113 (44) Sequence Number: - Start / End Page: 12574 - 12579 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230