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  African trypanosomes as model system for functional analyses of microbial motility

Engstler, M., Heddergott, N., Krüger, T., Stellamanns, E., Uppaluri, S., & Pfohl, T. (2012). African trypanosomes as model system for functional analyses of microbial motility. In C. Tropea, & H. Bleckmann (Eds.), Nature-Inspired Fluid Mechanics (pp. 43-61). Heidelberg: Springer.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-80B6-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-80B7-C
Genre: Book Chapter

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 Creators:
Engstler, Markus, Author
Heddergott, Niko, Author
Krüger, Tim, Author
Stellamanns, Eric1, Author              
Uppaluri, Sravanti1, Author              
Pfohl, Thomas1, Author              
Affiliations:
1Group Dynamics of biological matter, Department of Dynamics of Complex Fluids, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063313              

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 Abstract: The locomotion of microorganisms in a microscopic world, where cells move through a fluid environment without using inertial forces, is a fascinating phenomenon in life science. Nature offers clever and inspiring strategies for selfpropelling in an environment of no inertia. The flagellate African trypanosome, which causes African sleeping sickness, moves with help of a flagellum, which is firmly attached to its cell body. The beating flagellum leads to a strong distortion of the cell body and therefore to a swimming agitation of trypanosomes. We have found that trypanosomes use a hydrodynamic mechanism to defend against host’s immune attacks. Owing to continuous and directional swimming, host-derived antibodies attached to surface glycoproteins of the cell are dragged to the posterior cell pole, where they are rapidly internalized and destroyed. In the following we present new methodology and techniques to quantify the movements of proteins and the motility of cells. Moreover trypanosome motility schemes and their influence on cellular lifestyle and survival strategies are characterized.

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Language(s): eng - English
 Dates: 2012
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1007/978-3-642-28302-4
ISBN: 978-3-642-28301-7
 Degree: -

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Title: Nature-Inspired Fluid Mechanics
Source Genre: Book
 Creator(s):
Tropea, Cameron, Editor
Bleckmann, Horst, Editor
Affiliations:
-
Publ. Info: Heidelberg : Springer
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 43 - 61 Identifier: -