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  Preparation of monodisperse block copolymer vesicles via flow focusing in microfluidics.

Thiele, J., Steinhauser, D., Pfohl, T., & Förster, S. (2010). Preparation of monodisperse block copolymer vesicles via flow focusing in microfluidics. Langmuir, 26(9), 6860-6863. doi:10.1021/la904163v.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-80A1-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-80A2-9
Genre: Journal Article

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 Creators:
Thiele, Julian, Author
Steinhauser, Dagmar1, Author              
Pfohl, Thomas1, Author              
Förster, Stephan, Author
Affiliations:
1Group Dynamics of biological matter, Department of Dynamics of Complex Fluids, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063313              

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 Abstract: We demonstrate that microfluidic flow devices enable a rapid, continuous, well-reproducible and size-controlled preparation of unilamellar block copolymer vesicles. The PDMS-based microfluidic device consists of perpendicularly crossed channels allowing hydrodynamic flow focusing of an ethanolic block copolymer solution in a stream of water. By altering the flow rate ratio in the water and ethanolic inlet channels, the vesicle size can be tuned over a large size range from 40 nm to 2 μm without subsequent processing steps manipulating size and shell characteristics. The ability of tuning the vesicle mean size over a range of several orders of magnitude with the possibility ofin situ encapsulation of active ingredients creates new opportunities for the preparation of tailored drug delivery systems in science, medicine and industry.

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Language(s): eng - English
 Dates: 2010-05-04
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1021/la904163v
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Title: Langmuir
Source Genre: Journal
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Publ. Info: Columbus, OH : American Chemical Society
Pages: - Volume / Issue: 26 (9) Sequence Number: - Start / End Page: 6860 - 6863 Identifier: ISSN: 0743-7463
CoNE: https://pure.mpg.de/cone/journals/resource/954925541194