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  Opposing mechanisms support the voluntary forgetting of unwanted memories

Benoit, R. G., & Anderson, M. C. (2012). Opposing mechanisms support the voluntary forgetting of unwanted memories. Neuron, 18(2), 450-460. doi:10.1016/j.neuron.2012.07.025.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-7C8A-D Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B08C-8
Genre: Journal Article

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 Creators:
Benoit, Roland G.1, Author              
Anderson, Michael C.1, Author
Affiliations:
1MRC Cognition and Brain Sciences Unit, Cambridge, United Kingdom, ou_persistent22              

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 Abstract: Reminders of the past can trigger the recollection of events that one would rather forget. Here, using fMRI, we demonstrate two distinct neural mechanisms that foster the intentional forgetting of such unwanted memories. Both mechanisms impair long-term retention by limiting momentary awareness of the memories, yet they operate in opposite ways. One mechanism, direct suppression, disengages episodic retrieval through the systemic inhibition of hippocampal processing that originates from right dorsolateral prefrontal cortex (PFC). The opposite mechanism, thought substitution, instead engages retrieval processes to occupy the limited focus of awareness with a substitute memory. It is mediated by interactions between left caudal and midventrolateral PFC that support the selective retrieval of substitutes in the context of prepotent, unwanted memories. These findings suggest that we are not at the mercy of passive forgetting; rather, our memories can be shaped by two opposite mechanisms of mnemonic control.

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Language(s): eng - English
 Dates: 2012-07-312012-10-172012-10-18
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuron.2012.07.025
PMID: 23083745
PMC: PMC3480638
Other: Epub 2012
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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 18 (2) Sequence Number: - Start / End Page: 450 - 460 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565