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  Candidate editases for GluR channels in single neurons of rat hippocampus and cerebellum

Köhr, G., Melcher, T., & Seeburg, P. H. (1998). Candidate editases for GluR channels in single neurons of rat hippocampus and cerebellum. Neuropharmacology, 37(10-11), 1411-1417. doi:10.1016/S0028-3908(98)00149-X.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-7AB7-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-7AB8-6
Genre: Journal Article
Alternative Title : Candidate editases for GluR channels in single neurons of rat hippocampus and cerebellum

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Neuropharmacol_37_1998_1411.pdf (Any fulltext), 248KB
 
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 Creators:
Köhr, Georg1, Author              
Melcher, Thorsten1, Author              
Seeburg, Peter H.1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: ADAR; AMPA; Patch-clamp; RNA editing; RT-PCR
 Abstract: RNA editing by site selective adenosine deamination changes codons in several nuclear transcripts in the mammalian brain and affects critical properties of the encoded proteins, as exemplified by the calcium permeability of AMPA receptor channels. The recently cloned RNA dependent adenosine deaminases ADAR1, ADAR2 and ADAR3 form a small family of sequence-related candidate editases which are expressed in brain and other tissues at distinct levels and patterns. We have employed single-cell polymerase chain reaction of hippocampal CA1 and CA3 pyramidal neurons and cerebellar Purkinje and Bergmann glial cells in an attempt to evaluate the expression of these enzymes at a cellular level. We found ADAR2 expressed in all cells analyzed; approximately 50% of the cells co-expressed ADAR1 or ADAR3. The differential ADAR expression revealed by our study might underlie the distinct editing efficiencies and selectivities in different GluR subunit transcripts.

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Language(s): eng - English
 Dates: 1998-08-191998-11-211998-10-01
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: Neuropharmacology
  Other : Neuropharmacol.
Source Genre: Journal
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Publ. Info: Amsterdam [etc.] : Pergamon
Pages: - Volume / Issue: 37 (10-11) Sequence Number: - Start / End Page: 1411 - 1417 Identifier: ISSN: 0028-3908
CoNE: https://pure.mpg.de/cone/journals/resource/954925428257