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  Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo

Sprengel, R., Suchanek, B., Amico, C., Brusa, R., Burnashev, N., Rozov, A., et al. (1998). Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell, 92, 279-289. doi:10.1016/S0092-8674(00)80921-6.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-7BB6-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-7BB7-F
Genre: Journal Article
Alternative Title : Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo

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Sprengel, Rolf1, Author              
Suchanek, Bettina1, Author              
Amico, Carla2, Author              
Brusa, Rossella1, Author              
Burnashev, Nail2, Author              
Rozov, Andrej1, 2, Author              
Hvalby, Øivind, Author
Jensen, Vidar, Author
Paulsen, Ole, Author
Andersen, Per, Author
Kim, Jeansok J., Author
Thompson, Richard F., Author
Sun, William, Author
Webster, Lorna C., Author
Grant, Seth G. N., Author
Eilers, Jens, Author
Konnerth, Arthur, Author
McNamara, James O., Author
Seeburg, Peter H.1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: NMDA receptors, a class of glutamate-gated cation channels with high Ca2+ conductance, mediate fast transmission and plasticity of central excitatory synapses. We show here that gene-targeted mice expressing NMDA receptors without the large intracellular C-terminal domain of any one of three NR2 subunits phenotypically resemble mice made deficient in that particular subunit. Mice expressing the NR2B subunit in a C-terminally truncated form (NR2B(deltaC/deltaC) mice) die perinatally. NR2A(deltaC/deltaC) mice are viable but exhibit impaired synaptic plasticity and contextual memory. These and NR2C(deltaC/deltaC) mice display deficits in motor coordination. C-terminal truncation of NR2 subunits does not interfere with the formation of gateable receptor channels that can be synaptically activated. Thus, the phenotypes of our mutants appear to reflect defective intracellular signaling.

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Language(s): eng - English
 Dates: 1997-12-091997-09-121997-12-091998-01-23
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
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Title: Cell
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: 2 Volume / Issue: 92 Sequence Number: - Start / End Page: 279 - 289 Identifier: ISSN: 0092-8674
CoNE: https://pure.mpg.de/cone/journals/resource/954925463183